This presentation will examine the effect of the COVID-19 pandemic and its economic and labor consequences in cities and regions. How the pandemic is likely to alter work patterns in post-COVID urban and regional geography at intra- and inter-regional geographic scales will be assessed in the context of four main forces: the social scars infused by the pandemic; closure as a forced experiment; the need to secure the built urban environment against future risks; and changes in urban form and system. On a macrogeographic scale, we argue that COVID-19 is unlikely to significantly alter the winner's economic geography and spatial inequality in terms of employment. At the microgeographic scale, however, we suggest that it can cause a series of short-term and some long-term changes in the structure and morphology of urban employment. The durability and scope of these changes will depend on the timing and duration of the pandemic.